1° Klinischer Fall: Hemimastikatorischer Spasmus

In den vorangegangenen Kapiteln haben wir die diagnostische Komplexität in der Medizin betrachtet, wobei wir insbesondere einige Parameter berücksichtigt haben, wie die verborgenen Variablen, die uns nur die Entwicklung des Grundwissens im Laufe der Zeit ermöglichen wird, und die Schwierigkeiten bei der Entschlüsselung des verschlüsselten Signals, das das Zentralnervensystem in Form von verbaler Sprache nach außen sendet.

Nicht zuletzt die Einschränkungen durch eine deterministische Denkweise, die das Wissen in Fachkontexten reduziert, indem es seine diagnostische Kapazität einschränkt. Eine alternative Denkweise zur Deterministik, die in erster Linie eine Logik der Fuzzy-Sprache und den wichtigen Beitrag der Quantenwahrscheinlichkeit berücksichtigt, würde es uns ermöglichen, den wissenschaftlich-klinischen Horizont zu erweitern und in eine mesoskopische Realität einzutauchen.

In diesem Kapitel werden wir uns daher mit der Diagnose unserer Mary Poppins nach dem wissenschaftlich-klinischen Prozess befassen, die Schwierigkeiten der Implementierung und den Mehrwert des verschlüsselten Codes bewerten, der in der hepatischen Übertragung identifiziert wurde. 

 

Einführung

Ausgehend von dem, was in den vorangegangenen Kapiteln von der „Einführung“ bis zu den Kapiteln „Logik der Medizinersprache“ dargelegt wurde, sahen wir uns über die Komplexität der Argumente und die Unbestimmtheit der verbalen Sprache hinaus mit einem Dilemma konfrontiert, dem des Kontexts die der Patient überwiesen wird, und in diesen Fällen scheint es für unsere arme Mary Poppins den zahnmedizinischen Kontext zu dominieren, angesichts der positiven Behauptungen, die aus den klinischen und Labortests hervorgehen, die an dem Patienten durchgeführt wurden.

«dann triumphiert der Zahnarzt!»
(es scheint anscheinend aber ......)

Der klinische Fall unserer armen Mary Poppins zeigt die ganze physiopathologische und klinische Komplexität, aber vor allem ein Phänomen der Überschneidung von Aussagen, Aussagen und logischen Sätzen im zahnärztlichen und neurologischen Kontext, in dem ein Kontext Kompatibilität und Kohärenz erhält, während der andere Inkohärenz erhält.

Grundsätzlich angesichts der Kompatibilität und Konsistenz des Satzes $\Im _{o}$ (dentaler Kontext) mit den aus der klinischen Testberichterstattung abgeleiteten Behauptungen $(\delta _{1},\delta _{2},.....\delta _{n}\ )$, sagen konsequent, dass orofaziale Schmerzen durch eine temporomandibuläre Störung verursacht werden, die inkompatibel werden könnten, wenn eine andere Reihe klinischer Aussagen auftritt $(\gamma _{1},\gamma _{2},.....\gamma _{n}\ )$stimmten mit dem Satz überein $\Im _{n}$ (neurologischen Kontext) und kontextuell gegenüber, aus diagnostischer Sicht, zu$\Im _{o}$

Daher würde es eine Quelle für logistische Konflikte zwischen den beiden Fachkontexten mit unvermeidlicher diagnostischer Verzögerung geben, die auch den Entschlüsselungsprozess des Signals in der Maschinensprache des zentralen Nervensystems (ZNS) verunreinigen würde.

Was den Zugangsschlüssel zum Entschlüsseln des verschlüsselten Codes in Maschinensprache (SNC) bestimmt und es uns ermöglicht, eine Demarkationslinie abzufangen, werden unwiderlegbare klinische und / oder Labordaten genannt $\tau$, was die Konsistenz einer Behauptung bestätigt oder ausschließt als die andere. Es ist an dieser Stelle wesentlich, a $\Im _{d}$ Satz (Abgrenzungssatz) des Typs wird sein:

Hat Mary Poppins eine neuromotorische Störung oder eine temporomandibuläre Störung?

Wir erklären diesen Schritt im Detail:

Denken Sie daran, dass da 'Die Logik der klassischen Sprache' dies zeigt:

• A set of $\Im$ sentences, and a $n\geq 1$ number of other $(\delta _{1},\delta _{2},.....\delta _{n}\ )$ statements they are logically compatible if, and only if, the union between them $\Im \cup \{\delta _{1},\delta _{2}.....\delta _{n}\}$ it is consistent
• A set of $\Im$ sentences, and a $n\geq 1$ number of other $(\gamma _{1},\gamma _{2},.....\gamma _{n}\ )$ statements they are logically incompatible if, and only if, the union between them $\Im \cup \{\gamma _{1},\gamma _{2}.....\gamma _{n}\}$ it is inconsistent

Significance of contexts

Now, for the dental context we will have the following sentences and assertions to which we give a numerical value to facilitate the treatment and that is $\delta _{n}=[0|1]$ where $\delta _{n}=0$ indicates' normality' and $\delta _{n}=1$ 'abnormality' and therefore positivity of the report:

$\delta _{1}=$ Positive radiological report of the TMJ in Figure 2, $\delta _{1}=1\longrightarrow$ Abnormality, positivity of the report

$\delta _{2}=$ Positive CT report of the TMJ in Figure 3,$\delta _{2}=1\longrightarrow$ Abnormality, positivity of the report

$\delta _{3}=$ Positive axiographic report of the condylar traces in Figure 4, $\delta _{3}=1\longrightarrow$ Abnormality, positivity of the report

$\delta _{4}=$ Asymmetric EMG interference pattern in Figure 5, $\delta _{4}=1\longrightarrow$ Abnormality, positivity of the report

• 

  Figure 2: $\delta _{1}=$ Patient TMJ stratigraphy showing signs of condylar flattening and osteophytes

• 

  Figure 3: $\delta _{1}=$ Computed tomography of the TMJ showing flattening of the TMJ

• 

  Figure 4: $\delta _{1}=$ Axiography of the patient showing a flattening of the chewing pattern on the right condyle

• 

  Figure 5: $\delta _{2}=$ EMG interference pattern. Overlapping upper traces corresponding to the right masseter, lower to the left masseter.

The sentence $\Im _{o}$ (dental context) with a number $n\geq 1$ of other logically compatible $(\delta _{1},\delta _{2},.....\delta _{n}\ )$ assertions determine the union and coherence between them $\Im _{o}\cup \{\delta _{1},\delta _{2}.....\delta _{n}\}$ and are represented with a mathematical formalism to facilitate the diagnostic dialectic in the following way:

$\Im _{o}\cup \{\delta _{1},\delta _{2}.....\delta _{n}\}\rightarrow \Im _{o}\cup \{1,1.....1\}=1$

which represents the average of the individual statements reported. The average was designed because it can often happen that some tests give negative answers to which to give the value $\delta _{n}=0$

The result in this case is $\delta _{n}=1$ and at the same time it derives the coherent statement of the sentence $\Im _{o}$ in which it is argued that the symptomatology of the patient Mary Poppins is determined by the presence of a DTMs.

«But, paradoxically, in the neurological context $\Im _{n}$ we will have the same rational process:»
(and it is precisely here that the contexts conflict)

In the neurological context, therefore, we will have the following sentences and assertions to which we give a numerical value to facilitate the treatment and that is $\gamma _{n}=[0|1]$ where $\gamma _{n}=0$ indicates 'normality' and $\gamma _{n}=1$ 'abnormality' and therefore positivity of the report:

$\gamma _{1}=$ Absence of jaw jerk in Figures 6, $\gamma _{1}=1\longrightarrow$ Abnormality, positivity of the report

$\gamma _{2}=$ Absence of the silent masseterine period in Figures 7, $\gamma _{2}=1\longrightarrow$ Abnormality, positivity of the report

$\gamma _{1}=$ Hypertrophy of the right masseter on CT in Figures 8, $\gamma _{3}=1\longrightarrow$ Abnormality, positivity of the report

• 

  Figure 6: ${\gamma _{1}}=$ Jaw jerk detected electrophysiologically on the right (upper traces) and left (lower traces) masseters

• 

  Figure 7: $\gamma _{2}=$ Mechanical silent period detected electrophysiologically on the right (upper overlapping traces) and left (lower overlapping traces) masseters

• 

  Figure 8: $\gamma _{3}=$ CT shows evident hypertrophy of the right masseter

Now consequently also sentence $\Im _{n}$ with a number $n\geq 1$ of other logically compatible statements $(\gamma _{1},\gamma _{2},.....\gamma _{n}\ )$ determine the union and coherence between them $\Im _{n}\cup \{\gamma _{1},\gamma _{2}.....\gamma _{n}\}$ and the formal representation will be similar to that of the dental context:

$\Im _{n}\cup \{\gamma _{1},\gamma _{2}.....\gamma _{n}\}\rightarrow \Im _{n}\cup \{1,1.....1\}=1$ with contextual coherent affirmation of sentence $\Im _{n}$ in which it is argued that the symptomatology of the patient Mary Poppins has a neuromotor cause and the clinical consequences of a masticatory occlusal type are nothing other than a consequence of the neuropathic damage.

«In this scenario both the statements $\Im _{o}$ and $\Im _{n}$ are compatible, consistent and therefore true until a 'demarcator of coherence' is found which we previously called $\tau$»

Demarcator of coherence $\tau$

The $\tau$ is a representative clinical specific weight, complex to research and fine-tune because it varies from discipline to discipline and for pathologies, essential in order not to make logical assertions collide $\Im _{o}$ and $\Im _{n}$ in the diagnostic procedures and essential to initialize the decryption of the logic communication code. Basically it allows you to confirm the consistency of a union $\Im \cup \{\delta _{1},\delta _{2}.....\delta _{n}\}$ with respect to another $\Im \cup \{\gamma _{1},\gamma _{2}.....\gamma _{n}\}$ and vice versa, giving greater weight to the severity of the statements and the report in the appropriate context.

Sometimes the physician is faced with a series of positive reports to which to give due weight, he must consider the positivity of a report that highlights, for example, an osteoarticular remodeling of the TMJ cannot have the same weight as a positivity of a report confirming a latency delay of a trigeminal reflex.

The weight of demarcation $\tau$, therefore, gives more significance to the most serious assertions in the clinical context from which they derive and therefore beyond the positivity of the $\delta _{n}=1$ or $\gamma _{n}=1$ assertions which in any case are always verified and respected, these must be multiplied by a $\tau =[0|1]$ where $\tau =0$ indicates 'Low severity' while $\tau =1$ 'High severity'.

In the neurological context, $\tau$ concerns the presence of delays and/or latency absence of the jaw jerk, duration and/or absence of the masseterine silent period as well as other parameters that for the moment it is not necessary to describe. A delay greater than the normative value or an absence of the aforementioned tests is considered as a serious and absolute specific weight corresponding to a dominant valence with respect to the other clinical context.

To recap we therefore have:

$\Im _{o}\cup \{({{\bar {\delta }}_{n})}\tau _{o}+\Im _{n}\cup \{({{\bar {\gamma }}_{n})}\ \tau _{n}=\Im _{d}$

where

${{\bar {\delta }}_{n}}=$ average of the value of clinical statements in the dental context and therefore ${{\bar {\delta }}_{n}}=1$

${{\bar {\gamma }}_{n}}=$ average of the value of clinical statements in the neurological context and therefore${{\bar {\gamma }}_{n}}=1$

$\tau _{o}=0$ low severity performance of the dental context$\tau _{n}=1$reporting of high severity of the neurological context

where the 'coherence marker '$\tau$' will define the diagnostic path as follows

$\Im _{o}\cup \{1,1.....1\}0+\Im _{n}\cup \{1,1.....1\}\ 1=\Im _{d}\longrightarrow \Im _{d}=\Im _{n}\cup \{1,1.....1\}\ 1\longrightarrow \Im _{d}=\Im _{n}$

«This formal logic syntax procedure allowed us to eliminate the interference of low clinical severity assertions and quickly define a neurological rather than dental diagnostic path through the definition of $\Im _{d}=\Im _{n}$»

Once we have washed away the myriad of positively reported normative data, which generate conflicts between contexts, thanks to the coherence marker $\tau$ we have a much clearer and more linear picture on which to deepen the analysis of the functionality of the Central Nervous System. Consequently we can concentrate on intercepting the tests necessary to decrypt the machine language code that the SNC sends out converted into verbal language.

Ephaptic transmission

With a little effort and patience on the part of passionate readers who have followed the entire logical path, sometimes apparently off topic, we have reached a clinical picture in which the code to be decrypted is inherent in neuromotor damage. Consequently, the access keys to the code, the one that figuratively corresponds to the exact decryption algorithm, would correspond to the right choice of the neuromotor damage detector test.

This is a point where it is essential to infer the clinician's intuition because finding the right algorithm to decrypt the code, after the aforementioned filter steps that have been described to wash away the interference of assertions, means at least choosing the right dictionary, for example, that of the image (MR of the brain rather than the neck); acoustic and vestibular evoked potentials (if a vestibular scwannoma is suspected) or trigeminal electrophysiological study (if more than one trigeminal involvement is suspected).

In this clinical iter that we have presented, the choice of the clinician to follow the electrophysiological trigeminal roadmap from which the positivity of the ${\bar {\gamma _{n}}}=1$ assertions have already been derived, therefore, having already defined a picture of serious anomaly of absence of the jaw jerk and of the silent period masseterino on the right side of the patient will have to understand if the damage is intracranial or extracranial.

To do this, the clinician uses an electrical stimulation test of the masseter nerve in infratemporal fossa called $M-wave$ on the masseter muscle with simultaneous recording of the heteronymous $H-wave$ on the temporal muscle and a bilateral transcranial electrical stimulation of the trigeminal motor roots called, precisely, $_{b}Root-MEPs$

M-wave

The right masseter nerve was electrically stimulated in the infratemporal fossa (see clinical procedure chapter: Encrypted code: Ephaptic transmission) with a technique similar to that described by Macaluso & De Laat (1995). Square cathode pulses (0.1 ms) generated by an electrical stimulator (Neuropack X1, Nihon Kohden Corporation, Tokyo, Japan) were delivered through a Teflon-coated monopolar needle electrode (TECA 902-DMG25, 53534) with a tip non-isolated (diameter 0.36 mm; area 0.28 mm2) inserted 1.5 cm through the skin below the zygomatic arch and anterior to the temporomandibular joint in the infratemporal fossa with electrical shocks of 0.5 - 5 mA, and 0.1 ms. The anode was a surface non-polarizable Ag-AgCl disc electrode (OD 9.0 mm) positioned over the ipsilateral ear lobe. Electrical stimulation of the masseter nerve never produced pain, and the subjects only perceived muscle contraction. The correct position of the stimulation electrodes was monitored throughout the experimental session by checking online the size of the M wave in the masseter muscle. The signals were recorded by placing surface electrodes on the masseter and temporal muscles and filtered at 10-2000Hz and by concentric needle electrodes inserted into the anterior temporal muscle.

«The response in the right masseter was clearly delayed but relatively symmetrical in amplitude between sides. (Fig. 9)»

_bRoot-MEPs

The trigeminal root was stimulated transcrally through high voltage, low impedance through an electrical stimulator (Neuropack X1, Nihon Kohden Corporation, Tokyo, Japan)) with the anode electrode positioned at the apex and the cathode approximately 10 cm laterally from the apex along a line vertex acoustic meatus. The electric field is believed to excite the trigeminal motor nerve fibers via the trancranial route, near their exit from the skull. Also in this case, the response in the right masseter was markedly delayed (3.5 ms on the right side 2 ms on the left and dispersed. amplitude of the M-wave.

Figure 9: The responses evoked by stimulation of the masseter nerve M-wave and the trigeminal Root-MEPs are clearly delayed on the right side while maintaining the amplitude relatively symmetrical.

Having highlighted, through the execution of the $M-wave$ and $_{b}Root-MEPs$ test, a delay in the conduction speed of the trigeminal nerve fibers generates the suspicion that it is a focal demyelination. This indicates that the problem is to be referred to the nervous component rather than to the muscular one, therefore, our attention should focus on the type of focal demyelination, extent of damage and presumably localization of the damage. The differential diagnosis at this point focuses on the type and area of the demyelinating damage, for example, if it is a damage exclusively referred to the masseterine motor nerve or the motor nerve of the temporal muscle is also involved, important for treatment with botulinum endotoxin. To resolve this doubt it is necessary to evoke a heteronymous $H-wave$ response from recording on the temporal muscle.

H-wave

The arrangement is similar to that previously described with regard to the $M-wave$ with the variant that the temporal muscle is recorded simultaneously with the stimulation of the masseterine nerve in the intratemporal fossa by a bipolar needle electrode. The stimulation must be gradually adapted in order to evoke both a $M-wave$ from the masseter that a heteronymous $H-wave$ from the temporal muscle.

In our patient Mary Poppins, unfortunately, the neuromotor situation is quite complex and serious because to the infratemporal stimulation of the masseteral nerve we have a direct evoked response on the muscle ipsilateral to the stimulation (figure 10; $M-wave$) and at the same time not a heteronymous response (figure 10; $H-wave$ ) on the temporal muscle but rather a tonic asynchronous activity (Figure $E$)

This neurophysiopathological phenomenon is called 'Ephaptic transmission' and allows us to confirm the presence of demyelinating lesions also of the motor nerve of the temporal muscle.

As previously mentioned and in order not to burden the topic, the detailed description of the 'Hephaptic' phenomenon will be treated in the chapter 'Encrypted code: Ephaptic transmission' in order to better understand the physiological responses of heteronymous $H-wave$ by pathological ones.

Figure 10: On the right indicated with EMG the recording of the motor unit discharge on the right masseter at the time of the spasm is shown while on the right below indicated with M-wave we can see two motor potentials evoked by the electrical stimulation in infratemporal fossa recorded on the masseter. With H-wave it is possible to note the recording of the heteronomous H-wave on the temporal ipsilateral to the stimulation.

Conclusions

Following this step by step path we have demonstrated a peripheral motor nerve injury as originally proposed by Kaufman. Conduction studies have shown a slowing of conduction in the extracranial course of masticatory nerve fibers without a reduction in the amplitude of $M-wave$ and obviously EMG signs of chronic denervation. The temporal muscle biopsy appeared histologically normal.

«These results indicate axon-sparing demielination.»

The absence of the jaw jerk on the diseased side indicates damage to the large diameter afferent fibers ($A\alpha$) from the neuromuscular spindles. A lesion of few afferents $A\alpha$ could easily abolish the jaw jerk.

Muscle nerve damage would not be explained only because patients with Hemimasticatory Spasm (HMS) do not have sensory disturbances but also because they often only have spasms in one or two levator mandibular muscles. These observations argue against damage to the motor root or to the intracranial portion of the mandibular nerve where the motor bundles are closely grouped, favoring damage to the individual muscle nerves that pass through the infratemporal fossa.

The mechanism of involvement of facial paroxysmal involuntary activity has been discussed by Kaufnan and by Thompson and Carroll who emphasized the close similarity between hemimasticatory and hemifacial spasm.

In EMG, these prolonged spasms fit perfectly into the description of cramps, that is, discharges of irregular motor units that progressively increase, leading to the recruitment of much of the muscle of synchronous discharges at speeds of 40 to 60 Hz. Common to hemifacial spasm and cramps however, ectopic EMG activities can also be detected.

This could be responsible for the high frequency of EMG discharges at a frequency of 100-200 Hz and the synchronization of the entire muscle or multiple muscles, and post-activity. The synchronization could be explained by the lateral spread of discharges from adjacent nerve fibers, generating a local re-excitation circuit. Posthumous EMG activity consists of paroxysmal discharges that may follow a voluntary orthodromic contraction or antidromic impulses, and is attributed to self-excitation of the same axons after the passage of an impulse.

In our patient Mary Poppins we observed a synchronization of the whole or a large part of the muscle involved in the spasm (fig 10, EMG); the self-excitation is evidenced by the recording of the evoked discharges following the response of the stimulation of the chewing nerves (Fig. 10, E). These results support the hypothesis that spontaneous activity 'arises' in a demyelinated peripheral nerve, a phenomenon called hepaptic.

In conclusion, the patient was affected by 'Hemimasticatory Spasm' mainly focused on the right masseter muscle but with indirect diffusion of the phenomenon to the right temporal muscle probably due to hepaptic activity due to the demyelination of the masticatory motor nerves in the infratemporal fossa. Botulinum endotoxin therapy was started immediately with total regression of the disease 10 years later.

«But how do we get to decrypt a machine language code?»
(we will try to describe it in the chapter 'Crypted code: Ephaptic transmission' at the end of the section 'Hemasticatory spasm')

Bibliography & references

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