Difference between revisions of "Encrypted code: Bilateral Motor Evoked Potentials of trigeminal root"

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This detailed summary examines the complex interrelationships between dental malocclusion, postural disorders, and trigeminal neurophysiopathology through the clinical case of a patient known as 'Balancer.' The patient's decade-long suffering from a meningioma at the base of the skull illustrates the challenges and potential misdiagnoses that can occur when traditional dental perspectives are applied without considering deeper neurophysiological issues. The text integrates a broad range of medical insights to argue for a more nuanced approach to diagnosing and treating conditions that straddle neurology and dentistry.
This analysis explores the complex relationships between dental malocclusion, postural disorders, and trigeminal neurophysiopathology through the case of 'Balancer,' a patient with a decade-long struggle with a skull base meningioma. This case highlights the challenges and misdiagnoses that can arise when traditional dental perspectives overlook deeper neurophysiological issues, advocating for a more nuanced approach to diagnosis and treatment. The chapter begins by addressing the limitations of axiomatic assumptions in medical diagnoses, particularly when dealing with the interplay between dental health and neurological conditions. 'Balancer's' symptoms were initially interpreted through a dental lens but later revealed significant neurological pathology.


Introduction
The narrative explores how 'Balancer's' meningioma affected both sensory and motor fibers of the trigeminal nerve, leading to severe symptoms misinterpreted as dental issues. This section underscores the importance of integrating neurophysiological data into dental diagnoses, especially for atypical or severe symptoms.
The chapter opens by highlighting the limitations of axiomatic assumptions in medical diagnoses, particularly in the complex interplay between dental health and neurological conditions. It introduces the case of 'Balancer,' whose symptoms were initially interpreted within a dental framework but later understood to be indicative of significant neurological pathology.


Trigeminal Neurophysiopathology and Misdiagnosis
The summary evaluates the diagnostic process, emphasizing the role of electrophysiological tests such as bRoot-MEPs and jaw jerk reflex assessments. These tests provided a clearer picture of the nerve damage than traditional dental evaluations and highlighted the need for medical imaging to confirm the meningioma's presence and impact.
The narrative delves into the specifics of trigeminal neurophysiopathology, explaining how the patient's meningioma exerted physical effects on both sensory and motor fibers of the trigeminal nerve system, leading to severe symptoms that were initially misinterpreted as dental issues. The discussion underscores the importance of considering neurophysiological data in dental diagnoses, particularly when patients present with atypical or severe symptoms that do not align with common dental disorders.


Diagnostic Challenges and Electrophysiological Insights
MRI results confirmed the meningioma's severe implications, showing brainstem displacement and raising questions about the tumor's early development stages. The section considers whether earlier detection through targeted electrophysiological testing could have changed the treatment course.
The summary critically evaluates the diagnostic process, emphasizing the role of electrophysiological tests such as the <sub>b</sub>Root-MEPs and assessments of the jaw jerk reflex. These tests revealed the extent of the damage more accurately than dental evaluations and highlighted the need for medical imaging to confirm the presence and impact of the meningioma.


MRI Findings and Neurological Complications
'Balancer's' case illustrates how symptoms like 'chewing difficulty' can be misleading. The narrative advocates for an integrated diagnostic approach that combines dental and neurological expertise to avoid oversimplified conclusions and inadequate treatments.
MRI results confirmed the severe implications of the meningioma, showing brainstem displacement and raising urgent questions about the initial stages of the tumor's development. This section reflects on whether earlier detection of the tumor through targeted electrophysiological testing could have altered the patient's treatment trajectory.


Misleading Symptoms and the Importance of Accurate Diagnosis
The use of a Cognitive Neural Network (CNN) in diagnosing 'Balancer's' condition is discussed, demonstrating how advanced data analysis can differentiate between dental malocclusions and serious neurological conditions. This section outlines the CNN's steps to refine the diagnosis and understand the underlying causes of symptoms.
The patient's case is used to illustrate how symptoms like 'chewing difficulty' can be misleading. The narrative argues for a more integrated diagnostic approach that combines dental and neurological expertise to avoid oversimplified conclusions that may lead to inadequate treatments.


Cognitive Neural Network (CNN) Diagnostic Model
The chapter concludes by discussing the broader clinical implications for dentistry and neurology. It calls for greater awareness of neurological conditions manifesting as dental symptoms and recommends interdisciplinary approaches in medical training and practice to prevent diagnostic errors.
The use of a Cognitive Neural Network (CNN) in diagnosing 'Balancer's' condition is discussed, showcasing how advanced data analysis techniques can aid in distinguishing between symptoms related to dental malocclusions and those stemming from serious neurological conditions. This section details the sequential steps taken through the CNN to refine the diagnosis and better understand the underlying causes of the patient's symptoms.


Clinical Implications and Future Directions
{{ArtBy|
The chapter concludes by discussing the broader clinical implications of the case for both dentistry and neurology. It calls for heightened awareness of the potential for neurological conditions to manifest through symptoms typically associated with dental issues and recommends more interdisciplinary approaches in medical training and practice to prevent similar diagnostic errors.
 
Summary
This summary not only provides a detailed recount of 'Balancer's' medical journey but also serves as a cautionary tale about the risks of compartmentalized medical thinking. It advocates for a holistic approach to patient care that respects the complex interconnections between different bodily systems and emphasizes the critical importance of accurate, comprehensive diagnostic practices in ensuring effective treatment outcomes.<blockquote>
== Keywords ==
'''Trigeminal Neurophysiopathology''' - Refers to the study of diseases that affect the trigeminal nerve, highlighting the nerve's role in conveying sensory information from the face to the brain. This term is crucial for medical content discussing neurological impacts on facial sensation and motor functions.
 
'''Dental Malocclusion''' - Describes the misalignment of teeth and how they fit together when the jaws are closed. This keyword is key for dental health content, focusing on how teeth alignment affects overall oral health and potentially other bodily functions.
 
'''Postural Disorders''' - Pertains to conditions that affect the posture or the way the body is positioned when standing or sitting. This term is particularly relevant in discussions about how spinal and muscular health can be influenced by neurological and dental health.
 
'''Meningioma''' - A type of brain tumor that forms from the meninges, the layers of tissue covering the brain and spinal cord. This keyword is critical for content on brain tumors, discussing symptoms, diagnosis, and treatment options.
 
'''Electrophysiological Tests''' - Refers to diagnostic tests that measure electrical activity in the body, such as nerve impulses. These tests are crucial in neurology content, especially in diagnosing and understanding the extent of nerve damage.
 
'''Jaw Jerk Reflex''' - A reflex that helps diagnose disorders of the trigeminal nerve by tapping the jaw and observing the response. This keyword is relevant for neurological examination content, focusing on reflex testing.
 
'''Cognitive Neural Network (CNN) in Diagnosis''' - Discusses the application of advanced data analysis techniques in medical diagnostics, especially for integrating and analyzing patient data for better diagnostic accuracy. This term is significant for content on medical technology and innovations in diagnostics.
 
'''MRI Findings in Neurology''' - MRI (Magnetic Resonance Imaging) findings that provide insights into brain and nerve conditions, essential for content related to medical imaging techniques and their applications in diagnosing neurological disorders.
 
'''Motor Evoked Potentials (MEPs)''' - A diagnostic measure of the electrical activity in response to stimulation of the motor cortex, used to assess the functionality of motor pathways, particularly relevant for neurophysiological testing content.
 
'''Neurological and Dental Integration''' - Focuses on the interdisciplinary approach between neurology and dentistry to tackle complex cases that exhibit symptoms affecting both the neurological and dental systems, crucial for content on comprehensive patient care and diagnostic strategies.</blockquote>{{ArtBy|
| autore = Gianni Frisardi
| autore = Gianni Frisardi
| autore2 = Giorgio Cruccu
| autore2 = Giorgio Cruccu
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The 'CNN' loop closure analy of course is based on the terminal article which basically describe five patients with cerebellar ataxia, neuropathy and vestibular areflexia syndrome (CANVAS) with chronic cough and lower limb muscle stretch reflexes preserve yourself.<ref name=":0">Jon Infante, Antonio García, Karla M Serrano-Cárdenas, Rocío González-Aguado, José Gazulla, Enrique M de Lucas, José Berciano. Cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) with chronic cough and preserved muscle stretch reflexes: evidence for selective sparing of afferent Ia fibres.J Neurol . 2018 Jun;265(6):1454-1462. doi: 10.1007/s00415-018-8872-1.Epub 2018 Apr 25.
The 'CNN' loop closure analy of course is based on the terminal article which basically describe five patients with cerebellar ataxia, neuropathy and vestibular areflexia syndrome (CANVAS) with chronic cough and lower limb muscle stretch reflexes preserve yourself.<ref name=":0">Jon Infante, Antonio García, Karla M Serrano-Cárdenas, Rocío González-Aguado, José Gazulla, Enrique M de Lucas, José Berciano. Cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) with chronic cough and preserved muscle stretch reflexes: evidence for selective sparing of afferent Ia fibres.J Neurol . 2018 Jun;265(6):1454-1462. doi: 10.1007/s00415-018-8872-1.Epub 2018 Apr 25.
</ref> In particular, somatosensory evoked potentials were absent or severely attenuated. Biceps and hamstring T-reflex recordings were normal, while the masseter reflex was absent or attenuated.<blockquote>[[File:Meningioma 2 by Gianni Frisardi.jpeg|link=link=Special:FilePath/Meningioma_2_by_Gianni_Frisardi.jpg|alt=|thumb|'''Figure 1:''' Neurological statement highlighting a severe right jaw jerk latency and amplitude abnormality]]The first observation to be made is that the patients were suffering from chronic spasmodic cough and the second observation was the preservation of the tendon reflexes of the lower limbs. In our patient 'Balancer', on the other hand, there was a total absence of the mandibular tendon reflex<ref>The history of examination of reflexes. Boes CJ.J Neurol. 2014 Dec;261(12):2264-74. doi: 10.1007/s00415-014-7326-7. Epub 2014 Apr 3.PMID: 24695995 </ref> (<math>\gamma_1</math>) so that the neurological damage was very evident at the trigeminal midbrain level. (Figure 1) The multifunctional contribution of the midbrain synaptic circuitry by the proprioceptive nerve endings ( <math>1a</math> e <math>\gamma</math>) are of primary importance both for posture and for cervico-oculomotor reflexes. A very interesting article by Yongmei Chen et al.<ref>Chen Y, Gong X, Ibrahim SIA, Liang H, Zhang J.. Convergent innervations of mesencephalic trigeminal and vestibular nuclei neurons onto oculomotor and pre-oculomotor neurons-Tract tracing and triple labeling in rats. PLoS One. 2022 Nov 28;17(11):e0278205. doi: 10.1371/journal.pone.0278205. eCollection 2022.PMID: 36441755 </ref> showed, through markers, how neurons afferent to the trigeminal mesencephalic nucleus (Vme) from the jaw muscles project to the oculomotor nuclei (III/IV) and their premotor neurons in the interstitial nucleus of Cajal (INC), a well-known pre-oculomotor center that vertically manipulates torsional eye movements.
</ref> In particular, somatosensory evoked potentials were absent or severely attenuated. Biceps and hamstring T-reflex recordings were normal, while the masseter reflex was absent or attenuated.<blockquote>[[File:Meningioma 2 by Gianni Frisardi.jpeg|link=link=Special:FilePath/Meningioma_2_by_Gianni_Frisardi.jpg|alt=|thumb|'''Figure 1:''' Neurological statement highlighting a severe right jaw jerk latency and amplitude abnormality]]The first observation to be made is that the patients were suffering from chronic spasmodic cough and the second observation was the preservation of the tendon reflexes of the lower limbs. In our patient 'Balancer', on the other hand, there was a total absence of the mandibular tendon reflex<ref>The history of examination of reflexes. Boes CJ.J Neurol. 2014 Dec;261(12):2264-74. doi: 10.1007/s00415-014-7326-7. Epub 2014 Apr 3.PMID: 24695995 </ref> (<math>\gamma_1</math>) so that the neurological damage was very evident at the trigeminal midbrain level. (Figure 1) The multifunctional contribution of the midbrain synaptic circuitry by the proprioceptive nerve endings ( <math>1a</math> e <math>\gamma</math>) are of primary importance both for posture and for cervico-oculomotor reflexes. A very interesting article by Yongmei Chen et al.<ref>Chen Y, Gong X, Ibrahim SIA, Liang H, Zhang J.. [https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/36441755/ Convergent innervations of mesencephalic trigeminal and vestibular nuclei neurons onto oculomotor and pre-oculomotor neurons-Tract tracing and triple labeling in rats.] PLoS One. 2022 Nov 28;17(11):e0278205. doi: 10.1371/journal.pone.0278205. eCollection 2022.PMID: 36441755 </ref> showed, through markers, how neurons afferent to the trigeminal mesencephalic nucleus (Vme) from the jaw muscles project to the oculomotor nuclei (III/IV) and their premotor neurons in the interstitial nucleus of Cajal (INC), a well-known pre-oculomotor center that vertically manipulates torsional eye movements.
   
   
The conceptual conclusion of the authors was that the Vme proprioceptive neurons of the masticatory projecting muscles at III/IV and INC would detect spindle activity to spatial changes of the jaw conditioned by the force of gravity and/or by the connection between the mandible during rotation of the head. Thus, the convergent innervation of Vme and MVN neurons on the oculomotor and pre-oculomotor nuclei would be a neuroanatomical substrate for the interaction of masticatory proprioception with vestibulo-ocular signals on the oculomotor system during vertical-torsional VOR. The contribution of this article obviously allows us to consider a correlation between the trigeminal system, posture and gait, therefore, the abnormal asymmetry of the jaw jerk could be related to a postural disorder of our patient 'Balancer'
The conceptual conclusion of the authors was that the Vme proprioceptive neurons of the masticatory projecting muscles at III/IV and INC would detect spindle activity to spatial changes of the jaw conditioned by the force of gravity and/or by the connection between the mandible during rotation of the head. Thus, the convergent innervation of Vme and MVN neurons on the oculomotor and pre-oculomotor nuclei would be a neuroanatomical substrate for the interaction of masticatory proprioception with vestibulo-ocular signals on the oculomotor system during vertical-torsional VOR. The contribution of this article obviously allows us to consider a correlation between the trigeminal system, posture and gait, therefore, the abnormal asymmetry of the jaw jerk could be related to a postural disorder of our patient 'Balancer'
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