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Difference between revisions of "Orofacial Pain"
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</ref> using Bayesian methodology, aimed to examine the association of TMD-related pain with severe headaches (migraine and TTH) over an 11-year follow-up period compared with the frequency approach. Frequentist statistics suffer from some limitations, most notably the reliance on large sample sizes to accurately determine effect sizes.<ref name=":5">Buchinsky FJ, Chadha NK. To P or not to P: backing Bayesian statistics. Otolaryngol Head Neck Surg. 2017;157(6):915–918. doi: 10.1177/0194599817739260</ref> Furthermore, contrary to the Frequentist methodology, Bayesian statistics do not provide a (fixed) result value but rather an interval containing the regression coefficient.<ref>Depaoli S, van de Schoot R. Bayesian analyses: where to start and what to report. Eur Heal Psychol. 2014;16:75–84.</ref> These intervals, called credible intervals (CI), place a probability on the best estimate among all possible values of the parameter estimates.<ref name=":5" /> | </ref> using Bayesian methodology, aimed to examine the association of TMD-related pain with severe headaches (migraine and TTH) over an 11-year follow-up period compared with the frequency approach. Frequentist statistics suffer from some limitations, most notably the reliance on large sample sizes to accurately determine effect sizes.<ref name=":5">Buchinsky FJ, Chadha NK. To P or not to P: backing Bayesian statistics. Otolaryngol Head Neck Surg. 2017;157(6):915–918. doi: 10.1177/0194599817739260</ref> Furthermore, contrary to the Frequentist methodology, Bayesian statistics do not provide a (fixed) result value but rather an interval containing the regression coefficient.<ref>Depaoli S, van de Schoot R. Bayesian analyses: where to start and what to report. Eur Heal Psychol. 2014;16:75–84.</ref> These intervals, called credible intervals (CI), place a probability on the best estimate among all possible values of the parameter estimates.<ref name=":5" /> | ||
<blockquote>[[File:Question 2.jpg|50x50px|link=https://wiki.masticationpedia.org/index.php/File:Question_2.jpg|left]]''' | <blockquote>[[File:Question 2.jpg|50x50px|link=https://wiki.masticationpedia.org/index.php/File:Question_2.jpg|left]]'''Probabilistic questions''' | ||
We agree with the considerations that emerged in the study by Buchinsky et al.<ref name=":6" /> because perhaps or fortunately we will never be able to create a formal language logic such as mathematics given the intrinsic randomness of biological models. Even the Bayes models, however, incorporate a conceptual limit which, if exceeded, would improve the probabilistic data and contextually the predictive value <math>P(M|Pos) | We agree with the considerations that emerged in the study by Buchinsky et al.<ref name=":6" /> because perhaps or fortunately we will never be able to create a formal language logic such as mathematics given the intrinsic randomness of biological models. Even the Bayes models, however, incorporate a conceptual limit which, if exceeded, would improve the probabilistic data and contextually the predictive value <math>P(M|Pos) | ||
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If we wanted to go into a little more detail on this topic, we would immediately realize that the limit of languages lies in the fact that in medicine we are cognitively accustomed to considering the variables (symptom/disease and vice versa) dependent and therefore commutable. If a patient is symptomatic and therefore ill and a sick patient is symptomatic, this explains the terms 'dependent variables and commutability'. In quantum probability the variables are considered independent and do not commute and therefore the result could be the following: | If we wanted to go into a little more detail on this topic, we would immediately realize that the limit of languages lies in the fact that in medicine we are cognitively accustomed to considering the variables (symptom/disease and vice versa) dependent and therefore commutable. If a patient is symptomatic and therefore ill and a sick patient is symptomatic, this explains the terms 'dependent variables and commutability'. In quantum probability the variables are considered independent and do not commute and therefore the result could be the following: | ||
</blockquote>{{q2|Could an asymptomatic person be ill?| | </blockquote>{{q2|Could an asymptomatic person be ill?|difficult question that needs a complex answer ... have patience and you'll see}} | ||
=== Conclusion === | === Conclusion === | ||
Orofacial pain together with temporomandibular disorders are very complex pathophysiological phenomena which, despite the spread of clinical protocols available to the clinician, must be considered objectively but critically. If we consider the clinical cases already presented and the limitations described regarding the measurement error, the machine language logic with the code decryption process and the limitations of the Bayesian statistical procedures we can realize as a differential diagnosis between Orofacial Pain from Temporomandibular Disorders and Orofacial Pain from Oromandibular Dystonia is not quite so appreciable. Therefore, we will present two clinical cases that will highlight the essential methodological and clinical points to perform a rapid and detailed differential diagnosis between Orofacial Pain due to Temporomandibular Disorders and Orofacial Pain due to Oromandibular Dystonia{{Bib}} | Orofacial pain together with temporomandibular disorders are very complex pathophysiological phenomena which, despite the spread of clinical protocols available to the clinician, must be considered objectively but critically. If we consider the clinical cases already presented and the limitations described regarding the measurement error, the machine language logic with the code decryption process and the limitations of the Bayesian statistical procedures we can realize as a differential diagnosis between Orofacial Pain from Temporomandibular Disorders and Orofacial Pain from Oromandibular Dystonia is not quite so appreciable. Therefore, we will present two clinical cases that will highlight the essential methodological and clinical points to perform a rapid and detailed differential diagnosis between Orofacial Pain due to Temporomandibular Disorders and Orofacial Pain due to Oromandibular Dystonia{{Bib}} | ||