Difference between revisions of "Draft:Introduction - en"

*'''''<math>P-value</math>''''': <br><!--60-->In medicine, for example, to confirm an experiment, a series of data coming from laboratory instruments or from surveys, the "''Statistical Inference''" is used, and in particular a famous value called "significance test" (P-value). <!--62-->Well, even this concept, now part of the researcher's genesis, is wavering. In a recent study, attention was focused on a "Campaign" conducted on "Nature" against the concept of "significance tests"<ref>{{cita libro  

  }}</ref>.<br /><!--63-->With over 800 signatories supporting important scientists, this "campaign" can be considered an important milestone and a "Silent Revolution" in statistics on logical and epistemological aspects<ref>{{cita libro  

  }}</ref>. <!--64-->The campaign criticizes the too simplified statistical analyses that can still be found in many publications to date.<br><!--65-->This eventually led to a discussion, sponsored by the American Statistical Association, which spawned a special issue of "The American Statistician Association" titled "''Statistical Inference in the 21st Century: A World Beyond  p <0,05''", containing 43 articles by forward-looking statisticians<ref name="wasser">{{cita libro  

  }}</ref>. <!--66-->The special question proposes both new ways to signal the importance of research results beyond the arbitrary threshold of a P-value, and some guides to conduct of research: the researcher should accept uncertainty, be reflective, open and modest in his/ her statements<ref name="wasser" />. <!--67-->Future will show whether or not those attempts to statistically better support science beyond the significance tests will be reflected in future publications<ref>{{cita libro  

  }}</ref>. <!--68-->In this field too, we are on the same wavelength as the Progress of Science according to Kuhn, in that we are talking about the re-modulation of some descriptive statistical contents within the scope of disciplinarity.

*'''<!--69-->Interdisciplinarity''': <br><!--70-->In science policy, it is generally recognized that ''science-based problem solving requires interdisciplinary research'' ('''IDR'''), as proposed by the EU project called Horizon 2020<ref>European Union, ''[https://ec.europa.eu/programmes/horizon2020/en/h2020-section/societal-challenges Horizon 2020]''</ref>. <!--71-->In a recent study, the authors focus on the question why researchers have cognitive and epistemic difficulties in conducting IDR. It is believed that the loss of philosophical interest in the epistemology of interdisciplinary research is due to a philosophical paradigm of science called "Physics Paradigm of Science", which prevents recognition of important IDR changes in both the philosophy of science and research.<br><!--72-->The proposed alternative philosophical paradigm, called "''Engineering Paradigm of Science''", makes alternative philosophical assumptions about aspects such as the purpose of science, the character of knowledge, the epistemic and pragmatic criteria for the acceptance of knowledge and the role of technological tools. Consequently, scientific researchers need so-called ''metacognitive scaffolds'' to assist them in the analysis and reconstruction of how "knowledge" is constructed in different disciplines.<br><!--73-->In interdisciplinary research, metacognitive scaffolds help interdisciplinary communication analyse and articulate how the discipline builds knowledge<ref name=":0">

==<!--74-->P-value ''vs.'' Interdisciplinarity==

<!--75-->Given the above, on a superficial view of the epistemic evolution of the Science, the two aspects of disciplinarity ("''Physics Paradigm of Science''", highlighting the anomaly) and Interdisciplinary ("''Engineering Paradigm of Science''", metacognitive scaffold), might seem to be in conflict with each other; in reality, however, as we are just going to see right in this chapter, they are two sides of the same coin because both tend to generate "Paradigmatic Innovation" without any conflict at all.

<!--76-->Now we could conclude that the "Innovations" are already "Progress of Science" in themselves, as stated in the article "''Scientific basis of dentistry''" by Yegane Guven, in which the effect of biological and digital revolutions is considered on dental education and daily clinical practice, such as personalized regenerative dentistry, nanotechnologies, virtual reality simulations, genomic information and stem cell studies.<ref>{{cita libro  

  }}</ref> <!--77-->The innovations mentioned by Guven are obviously to be considered as technological and methodological in nature; however, the Progress of Science does not move forward with this kind of Innovations, which are called "''Incremental Innovations''" and "''Radical Innovations''", but it occurs substantially through "''Paradigmatic Innovations''".

<!--78-->In the strictest sense of the phrase, "Paradigmatic Innovations" are essentially '''a change of thought and awareness''' that pervades the whole of humanity, starting from different social strata, from the Copernican scientific revolution to the current trend of Stochastic approach to the biological phenomenon<ref>{{cita libro  

<!--79-->In this epistemological context (in addition to other initiatives such as the ''Research Diagnostic Criteria'' in the field of the Temporomandibular Disorders — RDC/TMDs), of the Evidence Based Medicine (and other), the Masticationpedia project inserts itself in order to highlight the dialectics dynamism about the progress of the masticatory rehabilitation science. Masticationpedia tends, moreover, to highlight the anomalies that inevitably stimulate a change of thought and therefore a "Paradigmatic Innovation".

<!--80-->Before proceeeding, it could be appropriate to observe a very concrete and significant case.

==<!--81-->Malocclusion==

''<!--82-->Malocclusion'': <!--83-->it literally means a bad (''malum'', in Latin) closure of the dentition<ref><!--84-->The creation of the term is generally attributed to Edward Angle, considered the father of modern orthodontics, who coined it as a specification of ''occlusion'' to signal the incorrect opposition in closing of the lower teeth and upper, especially the first molar ([[:wikipedia:Edward Angle|Wikipedia]]); <!--85-->see {{cita libro  

  }}</ref>. <!--86-->The ''closure'' is easy to understand, we believe, but the epithet "''bad''" must be understood with care as well, because it is not as simple as it seems.

<!--87-->To briefly grasp the concept, in this first introductory reading we will try to present a simple but highly debatable question that involves a series of other questions in the field of masticatory rehabilitation and especially in orthodontic disciplines: ''what is "Malocclusion"?'' Bear in mind that in 2019, a Pubmed query about this term returned a result of "only" 33,309 articles<ref>Pubmed, ''[https://www.ncbi.nlm.nih.gov/pubmed/?term=%22malocclusion%22 Malocclusion]''</ref>, <!--88-->which says it all about the hypothetical terminological agreement on the subject; and, therefore, very meaningful conclusions could be drawn every now and then from these articles, such as the ones we reproduce in full from an article by Smaglyuk and collaborators, a somewhat "sensational" article that deals with the interdisciplinary approach in the diagnosis of malocclusions<ref name="Smaglyuk">{{cita libro  

<!--90-->Another noteworthy fact is that if in the same 2019 Pubmed was questioned on interdisciplinarity in the diagnosis of malocclusions, the result dropped drastically to just four articles<ref>Pubmed, ''[https://www.ncbi.nlm.nih.gov/pubmed/?term=interdisciplinary+diagnostics+of+malocclusions interdisciplinary diagnostics of malocclusions]''</ref>.

<!--91-->These premises to the "Malocclusion” question indicate, on one hand, an alert about anomalies that tend to activate Kuhn phase 4 and, on the other, a bifurcation in the epistemic choice on the subject: one that generates Incremental Innovations (others 33,309 articles, perhaps) and another that prefers a new gnoseological path of "Paradigmatic Innovation”.

<!--92-->Let’s try to approach part of the concept that considers the "Paradigmatic Innovation” as essential, asking ourselves for example:

<!--96-->We will answer this question by reporting a clinical case of evident “Malocclusion”.

<!--97-->Patient is with an occlusion that orthodontists call “Malocclusion” because it has a posterior unilateral crossbite and anterior openbite<ref>{{cita libro  

  }}</ref>; <!--98-->it is a malocclusion that can be treated with a fixed orthodontic therapy and possibly in combination with an orthognathic intervention<ref>{{cita libro  

  }}</ref>. <!--99-->Crossbite is another element of disturbance in normal occlusion because of which it is obligatorily treated together with the openbite<ref>{{cita libro  

<!--100-->It is self-evident that an observer with a ''deterministic mindset'' facing a phenomenon of such evident occlusal incongruity considers crossbite and openbite the cause of malocclusion (cause/effect) or vice versa; and it is obvious, as well, that the observer recommends an orthodontic treatment to restore a “Normocclusion”. This way of reasoning means that the model (masticatory system) is “normalized to occlusion”; and if read backwards, it means that the occlusal discrepancy is the cause of malocclusion and, therefore, of disease of the Masticatory System. (<!--101-->Figure 1a).  

<!--102-->But let's hear what the two players say, the dentist and the patient, in the informative dialogue.[[File:Bilateral Electric Transcranial Stimulation.jpg|thumb|'''<!--103-->Figure 1b:''' <!--104-->Motor evoked potential from electrical transcranial stimulation of the trigeminal roots. Note the structural symmetry calculated by the peak-to-peak amplitude on the right and left masseters.|400x400px]]

|<!--105-->The dentist tells the patient that he is suffering from severe malocclusion and that it should be treated to improve its aesthetics and chewing function. The patient, however, replies firmly: «''No way, I haven't the slightest idea to do it at all, doctor, because I might even have an unrepresentative smile, but I eat very well.''»<br><!--106-->The dentist’s reply is ready, so the practitioner insists by saying: «''but you have a serious malocclusion with an openbite and a unilateral posterior crossbite, you should already have problems with bruxism and swallowing, as well as posture.''»<br><!--107-->The patient closes the confrontation in a decisive way: «''absolutely false: I chew very well, I swallow very well and at night I snore alot so I don’t grind; besides, I’m a sportsman and I don’t have any postural disturbance''».

<!--108-->Now the conclusion remains very critical because we might be finding ourselves in front of a verbal language of the patient which is misleading because it is not specific and does not respond to a detailed physiopathogenetic knowledge of the occlusal state; or, paradoxically, we are otherwise facing a machine language converted into verbal language which guarantees the integrity of the system. At this point the situation is truly embarrassing because neither the patient nor the observer (dentist) will be able to say with certainty that the System is in a “Malocclusion” state.

[[File:Jaw Jerk .jpg|alt=|left|thumb|'''<!--109-->Figure 1c:''' <!--110-->Mandibular reflex evoked by percussion of the chin through a triggered neurological hammer. <br>Note the functional symmetry calculated by the peak-to-peak amplitude on the right and left masseters.|400x400px]]

<!--111-->It is precisely at this moment that one remembers the criticism of the American Statistician Association titled “''Statistical inference in the 21st century: A World Beyond p <0.05''”, which urges the researcher to accept uncertainty, be sensible reflective, open and modest in his statements<ref name="wasser" />: <!--112-->which basically translates into a search for interdisciplinarity.

<!--115-->Interdisciplinarity, in fact, could answer such a complex question; but it is nonetheless necessary to interpret the biological phenomenon of "“Malocclusion”" with a ''stochastic forma mentis of'' which we will discuss in detail later.

<!--116-->A stochastic observer may observe that there is a low probability that the patient, at the moment <math>T_n </math>, is in a state of occlusal disease, as the patient's natural language indicates ideal psychophysical health; he/she then concludes that the occlusal discrepancy could not be a cause of neuromuscular and psychophysical functional disorder. In this case, therefore, the Masticatory System can not only be normalized to the occlusion only, but a more complex model is needed too, so it has to be normalized to the Trigeminal Nervous System. The patient was then served a series of trigeminal electrophysiological tests to assess the integrity of his/her Trigeminal Nervous System in these “"Malocclusion”" clinical conditions.

[[File:Mechanic Silent Period.jpg|thumb|'''<!--113-->Figure 1d:''' <!--114-->Mechanical silent period evoked by percussion of the chin through a triggered neurological hammer. Note the functional symmetry calculated on the integral area of the right and left masseters.|400x400px]]

<!--117-->We can see the following output responses, which we report directly in figures 1b, 1c and 1d (with explanation in the caption, to simplify the discussion). These tests and their description by now should only be considered as “Conceptual Rationale” for the “Malocclusion” question; later they will be widely described and their analysis detailed in the specific chapters. It can already be noted in this first descriptive approach to the masticatory phenomenon that there is an evident discrepancy between the occlusal state (which at first would support the orthodoxy of classical orthodontics in considering it as “Malocclusive State”) and the neurophysiological data indicating incredible synchronization and perfect symmetry of the trigeminal reflexes.

<!--118-->These results can be attributed to anything less than a "malocclusion": we are obviously in front of an error of the logic Language in medicine, in this case it is in fact more appropriate to talk about...

==<!--120-->Conclusion==

<!--121-->Even before drawing conclusions, conceptual clarity must be made on some fundamental points which of course will be treated in detail in the specific chapters of Masticationpedia.

<!--122-->The Masticatory System should be considered as a “'''Complex System'''”<ref>''[[wikipedia:Complex system|Complex system]]'' <!--123-->in [https://en.wikipedia.org/wiki/ Wikipedia]</ref>, <!--124-->not as a Biomechanical System focused exclusively on dental occlusion, because in this sense the “Occlusion” is nothing more than a subset of the Complex System interacting with the other subsets, such as periodontal receptors, neuromuscular spindles, recruitment of motor units, central nervous system, temporomandibular joint, etc., to give shape to an “Emerging Behaviour”, the masticatory one.

<!--125-->The peculiarity of this concept is that it is not possible to interpret or predict the “Emerging Behaviour” of a System by extracting objective data from a single subset. Instead, ''the integrity of the System must be quantified in its entirety'', and only then can a segmentation of the whole be attempted to make an analytical description of the node itself. There are very important intellectual and scientific movements that are engaging with this issue; in this regard, the extraordinary work of Prof. Kazem Sadegh-Zadeh: ''Handbook of Analytic Philosophy of Medicine'' comes to mind.<ref>{{cita libro  

<!--126-->In the presented case, the question is resolved in the following language logic:

:<!--127-->The subsets of the Masticatory System (teeth, occlusion, Temporomandibular joints, muscles, etc.) are in a state of "Coherence” with the Central Trigeminal Nervous System (see figures 1b, 1c and 1d), so the term “Malocclusion” cannot be used, the phrase “Occlusal  Dismorphism” should be considered instead.

<!--129-->Going beyond the specialist perimeters of the disciplines, as previously reported on interdisciplinarity, helps expanding the diagnostic and therapeutic models as it can be seen in the [[OrthoNeuroGnathodontics on 2° Class patient|Clinical case]] in which a patient was treated with the OrthoNeuroGnathodontic method is reported.

<!--130-->In this way, an overall view of the entire Masticatory System is presented in order to gather the aesthetic and functional-neurophysiological components together to determine “Occlusal Stability” and to avoid “Relapses”, especially in orthodontic and orthognathic treatments.<ref>{{cita libro  

<!--131-->These are just some of the topics that will be covered extensively both in this chapter and in what we call “Extraordinary Science”. Meanwhile, in a fitting diversion our colourful friend ''Linus Sapiens'', the little yellow man on the left, asks us: