Difference between revisions of "Complex Systems/en"

  }}</ref>. Hence, to describe the impaired function of the hippocampus in a reduced situation or abnorme asticatory function, the authors employed an animal model (mice) called ‘Molarless Senescence-Accelerated Prone’ (SAMP8) in order to make a parallelism on man. In SAMP8 mice, to which the occlusion was modified, increasing the occlusal vertical dimension of about 0.1 mm with dental materials showed that the occlusal disharmony disrupts learning and memory. These animals showed an age-dependent deficit in space learning at Morris’s water. <ref>{{Cite book  

  }}</ref> These changes in the catecolaminergic and serotonergic systems, induced by occlusal disharmonies, clearly affect the innervation of the hippocampus. The conditions of increasing the vertical dimension alter neurogenesis and lead to apoptosis in the ippocampal gyrus by decreasing the expression of the ippocampal brain derived from neurotrophic factors: all this could contribute to the changes in observed learning in animals with occlusal disharmony.<ref name="MFCF" />